Re: p21 gene

From: phil osborn (
Date: Sat Apr 15 2000 - 23:54:58 MDT

>From: Robert Bradbury <>
>Subject: Re: p21 gene
>Date: Wed, 12 Apr 2000 09:29:32 -0400 (EDT)
>>I would take this report with a grain of salt, as there are going
>to be complex overlaps between "cell replication blocking",
>"cell senescence", "telomere rundown" and "aging". Teasing out
>the exact interactions is going to be difficult. Until we get
>all of the genes known, and can exactly study their regulation and
>expression patterns, this is going to be a case of the blind
>biologists holding onto different parts of the elephant.
>Its coming. I'd bet in less than 5 years the whole machinery for
>replication, blocking, apoptosis, etc. will be pretty much an
>open book.
Just a thought. Reading Arthur Koestler in the late '60's started me
thinking that in fact one useful way to approach the whole genetic system is
to assume that you're dealing with a very sophisticated computational system
- microcode, error checking, meta-constructs, objects, ect. Many of
Koestler's speculations were along these lines and have mostly proven
correct. So you think of how you would design such a thing, if it were up
to you, then you try to imagine how such a feature might have evolved, and
where to look for evidence for it.

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