fixing cancer - Bcl-10 news

Damien Broderick (
Sun, 10 Jan 1999 12:00:27 +0000

< Normal p53 and Bcl-10 molecules, Wilkinson explains, "act as quality control inspectors, preventing cancerous cells from reproducing. Mutant Bcl-10 makes cells
cancerous." Mutant Bcl-10 not only prevented abnormal cells from dying and speeded
up their reproduction - like p53 - but also, the scientists found, actively changed cells so
they become malignant.

P53 research has advanced to the point of looking at treatments putting normal p53
molecules into cells. The BBC say that Dr. Dyer expects this Bcl-10 discovery to make
it easier to develop effective treatment—if scientists can find a way of switching off the
mechanism which makes cells malignant. >

Damien Broderick