Re: junk DNA

Geoff Smith (
Tue, 3 Mar 1998 00:18:10 -0800

> From: Thom Quinn <>
> To:
> Subject: junk DNA
> Date: Monday, March 02, 1998 8:18 PM
> Hello, I am looking for a good review paper about the
> various hypotheses on the possible functionality of
> so-called junk DNA--the non-coding regions of eukaryotic
> genomes. I am aware of some of the ideas (selfish DNA,
> genome structural functions, etc.) but I would like to find
> a review in the primary literature. Does such a thing exist?

Selfish DNA, genome structural functions, and regulatory action(eg.
heterochromatin and position-effect variegation) are all I can think of.
Maybe you could check out some articles on transposons and/or
heterochromatin. These articles are everywhere, and there are also many
books on the subject. Here's a review paper on heterochromatin by a
professor here at UBC:

Grigliatti, T. A. 1991. "Position Effect Variegation- An Assay for
Non-histone Chromosomal Proteins and Chromatin Assembly and Modifications
Factors." Methods in Cell Biology 35: 587-627.

> Thanks for you help!
> Thom Quinn