Re: everything you know is wrong--again

From: Robert J. Bradbury (
Date: Sun Feb 03 2002 - 09:48:05 MST

On Sun, 3 Feb 2002, Damien Broderick wrote:

> No. *Both* strands contain genes, running in
> opposite directions. Did you know that? Am I the only idiot in the room?

I knew that... :-) I wouldn't go so far as to call oneself an "idiot"
for not knowing it. It isn't exactly obvious.

> Of course we all knew about reading frames and how they can overlap in some
> cases *on the same strand*. But this is entirely fresh to me.

Actually having a small gene within a gene might occur but
having interleaved genes coding in the same direction on
the same strand is likely to be pretty rare. The splice
joining signals have a pretty standard signature and separating
those for Gene A from Gene B would be pretty difficult if
they were interleaved.

The current mystery from my knowledge base is the degree of alternate
splicing that occurs and what regulates it.


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