Technotranscendence writes:
> It would be nice to take this work and apply it to antiaging and cryonics
> research. A few years ago, I suggested coming up with a mathematical model
Yes, that's the idea behind it.
> of cryopreservation so as to come up with better cryoprotectants through use
> of genetic algorithmns. (My assumption was the model would be highly
We first need a good water model. I haven't modelled freezing in large
volumes (it's on my todo list), but purportedly the freezing point is
totally off-key. Whether this is an artefact of small volumes, or the
water model, and inasmuch this invalidates studied impact of
cryoprotectants I do not know (but intend to find out).
> nonlinear and very complex so that this method of search would be better
> than trial and error or an exhaustive search.)
Virtual screening is very new, and requires a lot of resources, both
in terms of hardware and manpower.
> Anyone interested in this?
>
> And what is the current method of research on this? I hear about results,
Cryobiology is but a tiny subfied of a subfield, counting about 200
practitioners world-wide, most of them past their prime. Molecular
modelling is hence slow to enter the field.
> but I'm not sure about the program. I assume it's basically trial and error
> because the results seem disjointed.
Thanks to Greg Fahy, we seem to understand colligative cryoprotectant
mixes more or less well now.
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