From: Robert J. Bradbury (bradbury@aeiveos.com)
Date: Fri Jun 06 2003 - 08:35:59 MDT
On Thu, 5 Jun 2003, Joao Magalhaes wrote:
> Robert, can you repeat the reference to this revised number of human genes?
The reference is to a recent meeting a Cold Spring Harbor.
The actual article (from the NY Times) is pointed to here:
Joao Magalhaes <jpnitya@sapo.pt>
http://forum.javien.com/XMLmessage.php?id=id::OiwMFgsm-OEYl-XX5b-fmNG-KjRwKT4uJxYU
(or you can backtrack through the forum messages under the
topic cited to get to it I think)
> Also, do you know if human coding regions are bigger than that of other
> species? For instance, we may have twice as many genes than bread mold but
> our genes may be twice as big and therefore have twice as many functions.
> Just wondering.
I do not believe that human coding regions are "on average"
significantly larger than other species.
There are a few genes, dystrophin is one that comes to mind,
involved in physical structures that one may not require in
simple organisms, that are I believe very large.
Most of the complexity seems to be coming from alternate splicing.
A report I recently read suggested that in higher organisms
(e.g. humans) there may be an average of 3 proteins coming
from each gene. That is a *lot* considering that for many
genes probably only one protein is produced. It is going
to make working out the proteomics a bear of a problem.
Robert
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