RE: specific amino acid restriction does the same thing as calorie restriction?

From: Damien Broderick (damienb@unimelb.edu.au)
Date: Tue Apr 22 2003 - 00:16:49 MDT

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    At 04:17 PM 4/21/03 -0700, Rafal wrote:

    >I like your idea of transferring
    >mtDNA-encoded function to the nucleus. Any more information on this project?

    I like the idea of using heavy-duty nuclear maintenance and repair
    mechanisms to keep our mitos nice, but I find it hard to see how this would
    work. You surely can't replace the work of a zillion cytoplasmic machines
    by one or a hundred nuclear-embedded versions. Besides, wouldn't that
    require the helix to be pulled open and naked all the time at that locus,
    which can't be a good look for DNA.

    Damien Broderick



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