Re: Aging Gene

From: Robert J. Bradbury (bradbury@aeiveos.com)
Date: Thu Apr 17 2003 - 06:57:15 MDT

  • Next message: Dehede011@aol.com: "The Middle east -- was a couple of other things"

    On Wed, 16 Apr 2003, Keith Elis wrote:

    > Two-for-one. Hutchinson-Gilford Progeria syndrome gene found. Oddly
    > linked to above average intelligence?
    >
    > http://story.news.yahoo.com/news?tmpl=story&ncid=514&e=8&cid=514&u=/ap/2
    > 0030417/ap_on_he_me/aging_gene

    Damn, I nearly flew out of the bed watching the early morning news
    today when I saw an item on one of the trailers that run across the
    bottom of the screen thinking I had a "hot" item of interest for
    the ExI list only to find its "old news".

    At any rate...

    The Science Daily URL is:
      http://www.sciencedaily.com/releases/2003/04/030417080108.htm

    The Nature Science Update URL is:
      http://www.nature.com/nsu/030414/030414-8.html

    Eureka Alert:
      http://www.eurekalert.org/pub_releases/2003-04/nhgr-rig041603.php

    GenBank mRNA variants (with PubMed links):
      http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list_uids=27436945&dopt=GenBanke
      http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list_uids=27436944&dopt=GenBankBb
      http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list_uids=27436947&dopt=GenBankCb

    Of interest is that the gene, LMNA, can cause at least 6 other
    genetic disorders -- now *that* is unusual.

    Though the Eureka Alert article says the gene is ~25,000 bases in size,
    the mRNA variants in Genbank suggest that it ranges from ~2000-3000 bases
    (probably alternate splice variations) so my guess would be that 25,000
    bases is the unspliced DNA code (25,000 bases would be unusually large
    for a typical gene).

    All I can say folks is that "Its now a done deal".
    We have the genome.
    We have the two accelerated aging disease genes.
    We have most, if not all, of the DNA repair genes
    (there are over 120 of these last time I checked).

    We still have to figure out how this all hangs together
    but if we can't do that within this decade then we
    ought to scrap the species and start over.

    Robert

    This archive was generated by hypermail 2.1.5 : Thu Apr 17 2003 - 07:06:56 MDT