From: Ramez Naam (mez@apexnano.com)
Date: Fri Apr 04 2003 - 11:19:15 MST
From: Rafal Smigrodzki [mailto:rafal@smigrodzki.org]
> Manganese-salen superoxide dismutase mimics interfere
> with the mitochondrial electron transport chain by acting as
> antimetabolites and thus effect "calorie restriction,"
> leading to extended lifespan.
Interesting. I wonder how relevant this is to creatures with
upregulated SOD production due to genetic engineering?
My first reaction is a bit skeptical. Creatures with increased SOD
production don't act like CR creatures. CR creatures are smaller and
have lower fertility.
On the contrary, mice and fruit flies with increased SOD levels have
normal body size and normal fertility.
I'm also not aware of any report from Melov et al of lower fertility
or body size in their study of nematodes treated with Euk-8 and
Euk-134 (which are presumably the manganese-salen SOD mimetics this
study is referring to).
But of course, biology defies our desire for simple answers.
mez
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