RE: Performance enhancement with selegiline

From: gts (gts_2000@yahoo.com)
Date: Mon Feb 10 2003 - 01:29:48 MST

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    Here is yet more evidence that selegiline (deprenyl) may increase
    life-expectancy in humans.

    In this study, treated animals enjoyed a 34% increase in life span.

    ABSTRACT:
    Deprenyl increases the life span as well as activities of superoxide
    dismutase and catalase but not of glutathione peroxidase in selective
    brain regions in Fischer rats

    Kitani K, Kanai S, Carrillo MC, Ivy GO

    Radioisotope Research Institute,
    Faculty of Medicine,
    University of Tokyo, Japan.
    Ann N Y Acad Sci 1994 Jun 30; 717:60-71

    ABSTRACT

    (-)Deprenyl, a MAO-B inhibitor that is also known to be effective for
    symptoms of Parkinson's disease, when injected subcutaneously (sc) in
    male Fischer-344 rats at a dose of 0.5 mg/kg per day (3 times a week)
    from 18 months of age, significantly increased the remaining life
    expectancy. The average life span after 24 months was 34% greater in
    treated rats than in saline-treated control animals. Furthermore, a
    short-term (3 wk) continuous sc infusion of deprenyl significantly
    increased activities of superoxide dismutase and catalase but not of
    glutathione peroxidase in selective brain regions such as s. nigra,
    striatum, and cerebral cortex, but not in hippocampus or cerebellum, or
    the liver. The optimal dose for increasing these activities, however,
    differed greatly depending on the sex and age of animals, with a 10-fold
    lower value for young female than male rats. Interestingly, aging
    caused an increase and a decrease in the optimal dose in female and male
    rats, respectively. In addition, treatment for a longer term tended to
    reduce the optimal dosage in the same animal group. The results clearly
    demonstrate that deprenyl increases antioxidant enzyme activities in
    selective brain regions. If this effect of deprenyl is causally related
    to its life-prolonging effect, the dosage to be used for any life span
    study would be a critical factor, with the dosage differing widely
    depending on sex, age of animal, and mode and duration of drug
    administration.



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