RE: Dolly and telomerase

Cameron Reilly (
Tue, 5 Oct 1999 17:43:42 +1000

so I wonder how this relates to the news that Dolly has shorter telomeres that a normal sheep her age?

> -----Original Message-----
> From:
> []On Behalf Of Damien Broderick
> Sent: Wednesday, October 06, 1999 2:40 AM
> To:
> Subject: Dolly and telomerase
> The most astounding fact I picked up in my conversations with Dr
> Jack Cohen
> (and then half lost, having no search facilities with me and not even a
> notebook, so what follows is garbled and unreliable) is that Dolly came
> from a batch of attempts in which Dr Wilmut tried to insert the telomerase
> gene into the clones. Amazingly, all those embryos which incorporated
> telomerase failed; Dolly's genome, however, proved *not* to have taken up
> the gene.
> I was agog at this. Cohen had got it from conversation with Wilmut, I
> believe, although he said it had been published a few months ago in some
> relatively obscure place. (I must be making that bit up - how could
> anything Wilmut has to say about Dolly end up somewhere obscure?)
> Anyway, this is all rather startling if correct. Might put a crimp in our
> plans for Immortality Next Week.
> Anyone with better net searching abilities than me should feel encouraged
> to post more details.
> Damien Broderick