Authors
Anisimov VN. Zabezhinski MA. Popovich IG. Lieberman AI. Shmidt JL.
Institution
Laboratory of Experimental Tumors, N.N. Petrov Research Institute of
Oncology, St. Petersburg, Russia. anisimov:anisimov.spb.ru
Title
Prevention of spontaneous and chemically-induced carcinogenesis using
activated carbon fiber adsorbent. I. Effect
of the activated carbon fiber adsorbent
'Aqualen' on spontaneous carcinogenesis and life-span in mice.
Source
Cancer Letters. 126(1):23-8, 1998 Apr 10.
Abstract
Female SHR mice were fed the activated
carbon fiber adsorbent Aqualen beginning at the age of 3
months through their life. Mice were fed Aqualen five times per week together
with lab chow at a daily dose of 100 mg/kg b.w. The addition of Aqualen into
food did not significantly influence the dynamics of body weight and the mean
life-span of the animals. At the same time, the age at 90% mortality of mice
was 4 months longer in the group exposed to Aqualen. There were no
statistically significant differences in the incidence of all tumors and
malignant tumors in the group of mice treated with Aqualen as compared with
the control group. However, in the group of mice exposed to Aqualen, there
was a 1.4 times reduction of the mean number of tumors per mouse. Feeding
mice with the adsorbent led to a 4 months longer life-span in animals with
any tumors and to a 5 months longer life-span in animals bearing malignant
tumors (P < 0.05). No carcinogenic effect of Aqualen was found. It could be
supposed that Aqualen has some geroprotective and anticarcinogenic
properties.