In a message dated 12/17/98 11:55:37 PM, firstname.lastname@example.org wrote:
>I don't think we have the technology
>to manipulate chromosomes at the level which would be necessary to change
>the sex of an embryonic cell. But it would certainly be an interesting
>experiment to do so and let the resulting male/female nearly-identical
No, no, that would be catastrophic - much worse than a brother-sister mating The child would have a 1/4 chance of expressing any deleterious recessive the original had masked by the normal gene, and for humans that's a lot. Such children would often die, and would be virtually guaranteed major genetic defects.
Cloning doesn't generate this problem as the chromosomes don't undergo meosis (swap genes). So masked recessives stay that way. There will be problems from accumulating mutations, but these should be minor for a couple of generations.