docosahexaenoic acid increases SRHSP lifespan
Doug Skrecky (email@example.com)
Sat, 5 Dec 1998 17:44:48 -0800 (PST)
Minami M. Kimura S. Endo T. Hamaue N. Hirafuji M. Monma Y. Togashi H.
Yoshioka M. Saito H. Watanabe S. Kobayashi T. Okuyama H.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health
Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
Effects of dietary docosahexaenoic acid on survival time and stroke-related
behavior in stroke-prone spontaneously hypertensive rats.
General Pharmacology. 29(3):401-7, 1997 Sep.
- Dietary docosahexaenoic acid (DHA) suppressed the age-dependent increase
in systolic blood pressure and prolonged the average survival time of
stroke-prone spontaneously hypertensive rats (SHRSP). 2.
Dietary DHA (1% and 5% in diets) altered the circadian rhythm of
SHRSP, causing significant increases in ambulatory activity
during the dark period. At the onset of stroke, desynchronization with light
and dark phases and new biological rhythms were noted in all of the control
SHRSP (DHA 0%). DHA treated SHRSP did not
show such behavioral changes. 3. These effects were accompanied by the
increase of DHA and the decrease of AA levels in plasma and brain cortex. 4.
It was concluded that dietary DHA suppresses the development of hypertension
and stroke-related behavioral changes, resulting in prolongation of the
SHRSP's life span.