The last show that really changed some fundamental ideas I had was PBS's "The Glorious Accident", now available as a boook. Here's the description:
by Wim Kayzer
Kayzer envisioned gathering together a group of renowned thinkers to discuss the all-encompassing question of what it is that we know about why we are here. He met individually with Oliver Sacks, Stephen Jay Gould, Daniel Dennett, Freeman Dyson, Rupert Sheldrake, and Stephen Toulmin, then gathered the group together for a discussion. By the time they had finished, they had addressed the nature of consciousness, what people derive most from consciousness -- knowledge or understanding, and such personal questions as what fascinated panel members as children and what drives them today.
Maybe available in video at your local library. Also greatly agree with Cosmos, Connections, The Ascent of Man(kind), and of course Pee Wee's Playhouse. ;-)