Authors
Battell ML. Delgatty HL. McNeill JH.
Institution
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences,
University of British Columbia, Vancouver, Canada.
Title
Sodium selenate corrects
glucose tolerance and heart function in STZ diabetic rats.
Source
Molecular & Cellular Biochemistry. 179(1-2):27-34, 1998 Feb.
Abstract
Sodium selenate, administered
intraperitoneally (i.p.), resulted in an improvement in
glucose tolerance in treated diabetic rats. Fed rat plasma
glucose levels were reduced by selenate
treatment in streptozotocin diabetic rats. The lowest values of blood
glucose were reached within 3 weeks of beginning the
treatment. Food and fluid consumption was reduced in treated compared to
untreated diabetic rats. Diabetic treated rats did not release insulin in
response to a glucose challenge and insulin release in
response to a challenge was markedly reduced in control treated rats.
Assessment of heart function using a working heart apparatus showed that
treated diabetic rats with improved blood glucose levels had
normal heart function at 8 weeks of diabetes in contrast to hearts from
non-treated diabetics. This study extends previous observations on the in
vivo insulin-like effects of sodium
selenate.