Authors
Okajima E. Tsutsumi M. Ozono S. Akai H. Denda A. Nishino H. Oshima S.
Sakamoto H. Konishi Y.
Institution
Department of Oncological Pathology, Cancer Center, Nara Medical University,
Kashihara.
Title
Inhibitory effect of tomato juice on rat
urinary bladder carcinogenesis after N-butyl-N-(4-hydroxybutyl)nitrosamine
initiation.
Source
Japanese Journal of Cancer Research. 89(1):22-6, 1998 Jan.
Abstract
The effects of tomato juice on urinary
bladder carcinogenesis were studied in male Fischer 344 rats initiated with
N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in rats. The animals (6 weeks
old) were given 0.05% BBN in their drinking water for 8 weeks, followed by
diluted tomato juice for 12 weeks, and
killed at 20 weeks after the beginning of the experiment. Lycopene
concentrations in the livers of rats given tomato
juice were elevated. Histopathological analysis of urinary
bladder lesions revealed the numbers, but not incidences, of urinary bladder
transitional cell carcinomas (TCCs) to be decreased in the group given
tomato juice. No influence on the incidence
of simple and nodullopapillary hyperplasias, invasion or differentiation of
TCC was noted. These results indicate that tomato
juice, presumably the contained lycopene and other
anti-oxidants in combination, exerts an inhibitory effect on the development
of TCCs in the rat urinary bladder.