Good post Doug,
Do you have references for curcumin and any sort of inhibition of
neoplasia???
cymm
-----Original Message-----
From: Doug Skrecky <oberon@vcn.bc.ca>
To: extropians-digest@extropy.com <extropians-digest@extropy.com>
Date: Tuesday, October 03, 2000 5:27 PM
Subject: myo-inositol best at inhibiting cancer progression
>Title
> Evaluation of butylated
> hydroxyanisole, myo-inositol, curcumin, esculetin,
> resveratrol and lycopene as inhibitors of benzo[a]pyrene plus
> 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis
in
> A/J mice.
>Source
> Cancer Letters. 137(2):123-30, 1999 Apr 1.
>Abstract
> The potential activities of butylated
> hydroxyanisole (BHA), myo-inositol, curcumin, esculetin,
> resveratrol and lycopene-enriched tomato oleoresin (LTO) as
chemopreventive
> agents against lung tumor induction in A/J mice by the tobacco smoke
> carcinogens benzo[a]pyrene (BaP) and
> 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were evaluated.
Groups
> of 20 A/J mice were treated weekly by gavage with a mixture of BaP and
NNK (3
> micromol each) for 8 weeks, then sacrificed 26 weeks after the first
> carcinogen treatment. Mice treated with BHA (20 or 40 micromol) by gavage
2 h
> before each dose of BaP and NNK had significantly reduced lung tumor
> multiplicity. Treatment with BHA (20 or 40 micromol) by gavage weekly or
with
> dietary BHA (2000 ppm), curcumin (2000 ppm) or resveratrol (500 ppm) from
1
> week after carcinogen treatment until termination had no effect on lung
tumor
> multiplicity. Treatment with dietary myo-inositol (30,000 ppm) or
esculetin
> (2000 ppm) from 1 week after carcinogen treatment until termination
> significantly reduced lung tumor multiplicity, with the effect of
> myo-inositol being significantly greater than that of esculetin.
Treatment
> with dietary LTO (167, 1667 or 8333 ppm) from 1 week before carcinogen
> treatment until termination had no effect on lung tumor multiplicity. The
> results of this study demonstrate that BHA is an effective inhibitor of
BaP
> plus NNK-induced lung tumorigenesis in A/J mice when administered during
the
> period of carcinogen treatment and that, among the compounds tested,
> myo-inositol is most effective after carcinogen treatment.
>
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