Aubrey de Grey's theory

Joao Pedro Magalhaes (
Wed, 01 Sep 1999 23:19:00 +0100


I have a couple of stupid questions -- particularly for someone working in gerontology. It goes like this, what evidences exist to support Aubrey de Grey's theory? Why the "counter-intuitive" argument? Sure it's elegant but I'm sure I can imagine others.

Also, you wrote:
>In rapidly dividing cells, this is not a problem, since membrane damage is
>cancelled out by fresh membrane creation.

Why is this relevant? I mean, what has the cellular membrane has to do with anything? Why don't you also mention ROS damage to nuclear DNA?

I understand the theory of accumulating mutant mitochondria, I just want to know evidences supporting it and why should it only affect post-mitotic cells?

Presumably you know something I don't -- I a haven't read his original article. I'd be thankful if you could give me an explanation on the subject.

Best wishes.