Stavrovskaia IG. Sirota TV. Saakian IR. Kondrashova MN. Institution
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. Title
[Optimization of energy-dependent processes in mitochondria from rat liver and brain after inhalation of negative air ions]. [Russian]
Biofizika. 43(5):766-71, 1998 Sep-Oct. Abstract
The effect of negative air ions (NAI) inhalation by rats on energy reactions of mitochondria in homogenates of liver and brain was studied. The influence of NAI was investigated under activation of animals by administration of physiological dose of adrenaline. Adrenaline administration induced hyperactivation of the rate of phosphorylating oxidation of succinic acid in liver and brain mitochondria which was accompanied by oxalacetate inhibition of succinate dehydrogenase (SDH) as well as excessive Ca2+ accumulation in liver mitochondria. These changes connected with a decrease of coefficient of phosphorylation efficiency ADP/O and uncoupler stimulation of respiration evidenced decrease of energy control of respiration in mitochondria. NAI inhalation diminished the rate of hyperactivated respiration and abolished excessive Ca2+ accumulation. These changes together with ADP/O coefficient and DNP stimulation increase evidence improvement of energy control of respiration which provide more moderate function of the respiratory chain under activation by adrenaline. Animals were excited by adrenaline administration. This effect was abolished by NAI inhalation, animals relaxed, some fell asleep. The data evidence sensitivity of mitochondrial processes in internal organs to inhalation of NAI and show participation of mitochondria in realization of physiological effects of NAI.
Additional comment by poster:
It would be very interesting to see the effects of large doses of
negative air ions in the setting of an old age home.
It would be very interesting to see the effects of large doses of negative air ions in the setting of an old age home.