I remember that when I first encountered the Extropian vision, there was very little SF that had put it all together. Then there were a few books that explored nanotech (Greg Bear, Michael Flynn), sort of by grafting it onto the present and letting some of the obvious implications drive the plot.
I am a few pages into Stephen Baxter's _Ring_ as I type, and it scores very high on Ex!meme uptake. So far, by page 37, we've got transformation of a human into something more by use of powerful nanobots, immortality conferred by anti-senescence treatments using nanites, wormhole travel, time loops ...
I use this address only when I am away from home. I have reply-to set to email@example.com and I read email sent to that address from here, so please don't use the yahoo address.