Authors
Moriguchi T. Saito H. Nishiyama N.
Institution
Department of Chemical Pharmacology, University of Tokyo, Japan.
Title
Aged garlic extract
prolongs longevity and improves spatial memory deficit in
senescence-accelerated mouse.
Source
Biological & Pharmaceutical Bulletin. 19(2):305-7, 1996 Feb.
Abstract
The effects of aged garlic
extract (AGE), chronically administered in the diet, on
longevity and spatial learning performances were studied using the
senescence-accelerated mouse (SAM). A solid diet containing 2% AGE was given
to senescence-accelerated-prone mouse 8 (SAMP8) and
senescence-accelerated-resistant mouse 1 (SAMR1) from 2 months of age. The
survival ratio of SAMP8, a substrain of senescence-accelerated-prone mouse,
was significantly lower than that of SAMR1, a substrain of
senescence-resistant mouse. In the SAMP8, administration of AGE perfectly
prevented the decrease in survival ratio. Moreover, AGE markedly improved the
learning deficits of SAMP8 in the Morris water maze test. These results
suggest the possibility that AGE prevents physiological aging and age-related
memory disorders in human.