Authors
Reddi A. DeAngelis B. Frank O. Lasker N. Baker H.
Institution
Department of Medicine, University of Medicine and Dentistry of New
Jersey-New Jersey Medical School, Newark 07107-3006.
Title
Biotin supplementation improves glucose and insulin
tolerances in genetically diabetic KK mice.
Source
Life Sciences. 42(13):1323-30, 1988.
Abstract
Because biotin treatment may lower blood glucose in
insulin-dependent diabetes, we chose to study such an effect
in non-insulin dependent diabetes. Twenty-six diabetic KK
mice, moderately hyperglycemic and insulin resistant, were treated for 10
weeks: 9 animals with 2 mg of biotin/Kg, 8 with 4 mg of
biotin/Kg, and 9 with saline (controls). Blood glucose
levels, oral glucose tolerance, insulin response to oral glucose, and blood
glucose decrease in response to insulin were quantitated. Compared to
controls, biotin treatment lowered post-prandial glucose
levels, and improved tolerance to glucose and insulin resistance. Serum
immunoreactive insulin levels in biotin-treated mice were
like the controls.