food restriction, deprenyl, nimodipine & the SHRSP rat

Doug Skrecky (
Thu, 2 Jul 1998 20:39:59 -0700 (PDT)

Neurobiology of Aging 19(3): 273-276 1998 "Long-Term Food Restriction, Deprenyl, and Nimodipine Treatment on Life Expectancy and Blood Pressure of Stroke-Prone Rats"


We determined whether food restriction or the drugs nimodipine (Ca2+ antagonist) and deprenyl (a MAO-B inhibitor) prevent the development of stroke in the spontaneously hypertensive stroke-prone rat (SHR-SP). Forty male SHR-SP rats, in the age of 34 weeks, were exposed to various treatments. During a period of 27 weeks, survival and blood pressure were followed. In the control and deprenyl group, the blood pressure values remianed unchanged; 50% had died after 27 weeks. All rats that were treated with nimodipine survived. After food restriction, 7/8 rats survived and showed a lower blood pressure. This study in SHR-SP rats shows the superiority of nimodipine on survival, and the potential of food restriction as a stroke-preventing measure.