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U.VA. RESEARCHERS FIND EVIDENCE OF SECOND GENETIC CODE
CHARLOTTESVILLE, Va., August 10
"The cell is somehow making choices about using
methylation to turn a gene on or off...
Allis and other researchers have co-authored several
studies that show evidence that histone methylation is at
the heart of this highly conserved molecular on/off
switch.
"Together this data indicates that this switch and
indexing system for our genome is most fundamental,
existing in even the simplest genetic
organisms like yeast, and has not changed with mammalian
evolution...
"Clear evidence is beginning to link alterations in
chromatin structure to cell cycle progression, DNA
replication, DNA damage and
its repair, recombination and overall chromosome
stability. If this histone code hypothesis is correct and
an on/off master switch
exists for genes that are housed in chromatin, the
implications for human biology and disease, including
cancer and aging, are far-reaching...
http://www.newswise.com/articles/2001/8/GENECODE.UVM.html
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