Title
[Lipid and lipoprotein
profile of Japanese centenarians--high prevalence of hypo
beta lipoproteinemia]. [Japanese]
Source
Nippon Ronen Igakkai Zasshi - Japanese Journal of Geriatrics. 34(3):202-8,
1997 Mar.
Abstract
To study the relationship between lipids and longevity, we
examined the level of serum lipids and
apolipoproteins, and the susceptibility of low density
lipoprotein (LDL) to oxidation of 45 centenarians (15 men,
30 women, mean age 101.1 +/- 1.4) living in the Tokyo metropolitan area. The
average levels of total cholesterol (TC), of LDL-C of high-density
lipoprotein cholesterol (HDL-C), and of
apolipoproteins A1 and B were significantly lower in
centenarians than in healthy middle-aged controls. The frequency of
hypobeta-lipoproteinemia (apoB < 60 mg/dl) in centenarians
was almost ten times as high as in controls. The time course of
copper-mediated LDL, oxidation (assessed by monitoring 234 nm diene
absorption (lag time)) did not significantly differ between the two groups.
Analysis of LDL subfractions by non-denaturated gradient-gel electrophoresis
showed a predominance of large, buoyant LDL particles (pattern A) in 75%, and
a predominance of small dense LDL particles (pattern B) in 25% of
centenarians. We also assessed activities of daily living (ADL) and cognitive
function in the centenarians. Centenarians were divided into two groups
according to the median ADL score, and were classified into five groups with
a scale clinical dementia. In subjects with good ADL scores, the mean
concentration of HDL-3-C was significantly higher than in those with poor ADL
scores. Average levels of HDL-C were also significantly lower in subjects
with moderate or severe dementia than in those with normal cognitive
function. These findings suggest that centenarians have protective phenotypes
of lipids and lipoproteins that protect
them from atheroscierosis.
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