Title
Serum glutathione in
adolescent males predicts parental coronary heart disease.
Source
Circulation. 100(22):2244-7, 1999 Nov 30.
Abstract
BACKGROUND: Traditional risk factors account for only half of the morbidity
and mortality from coronary heart disease (CHD). There is substantial
evidence that oxidative injury plays a major role in the atherosclerotic
process. Thus, antioxidants may protect against development of
atherosclerosis. Glutathione, an intracellular tripeptide
with antioxidant properties, may be protective. METHODS AND RESULTS: This
case-control study compared total serum
glutathione (tGSH) in 81 adolescent male
offspring of parents with premature CHD (ie, before 56 years of age) and 78
control male offspring of parents without known or suspected CHD. Case
offspring had significantly lower tGSH than control offspring. In multiple
logistic regression with parental CHD status as the dependent variable, age
entered as a covariate, and other CHD risk factors competing to enter the
model as significant independent predictor variables, LDL cholesterol (odds
ratio [OR], 2.15 [units=1.5 SD]; 95% CI, 1.21 to 3.82), tGSH (OR, 0.40; 95%
CI, 0.22 to 0.71), HDL cholesterol (OR, 0.42; 95% CI, 0.22 to 0.78), and
total serum homocysteine (OR, 2.6; 95% CI, 1.35 to 5.02)
entered the model as significant predictors of parental CHD status.
CONCLUSIONS: Low tGSH in adolescent boys is a significant
independent predictor of parental CHD, in addition to elevated LDL
cholesterol, low HDL cholesterol, and elevated total serum
homocysteine concentrations.
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