Authors
Freisleben HJ. Neeb A. Lehr F. Ackermann H.
Institution
Gustav-Embden-Zentrum der Biologischen Chemie, Laboratorium fur
Mikrobiologische Chemie, Frankfurt/Main Germany.
Title
Influence of selegiline and lipoic acid on
the life expectancy of immunosuppressed mice.
Source
Arzneimittel-Forschung. 47(6):776-80, 1997 Jun.
Abstract
Ten groups of 14 immunosuppressed NMRI-mice (nu/nu) were raised and kept
under germ-reduced conditions. The control animals were fed a germ-reduced
diet, nine other groups received the same diet with
selegiline (CAS 14611-51-9, Deprenyl) or lipoic acid
(thioctic acid, CAS 62-46-4) admixed at various amounts. The 50% survival
rate, the total life span of each group and the areas under the curves were
determined to evaluate life expectancy as compared to the controls. The
racemate of lipoic acid at high dosage (350 mg/kg body weight) reduced the
life span significantly. The S(-)-enantiomer of lipoic acid (75 mg/kg body
weight) increased the 50% survival rate, whereas the physiologic
R(+)-enantiomer (9 mg/kg body weight) expanded the total life span of its
group. Alteration of only one out of three parameters was not considered
significant. All other groups except for one did not differ from controls:
only animals which obtained 75 micrograms selegiline per kg
of body weight and per day exerted increased life expectancies by all three
parameters. This group exhibited also in statistical evaluation a
significantly (p < 0.05) prolongated survival time up to about 200% as
compared to the control animals.