Authors
Gallagher IM. Clow A. Glover V.
Institution
Department of Paediatrics, Queen Charlotte's & Chelsea Hospital, London,
United Kingdom.
Title
Long-term administration of
(-)-deprenyl increases mortality in male Wistar rats.
Source
Journal of Neural Transmission. Supplementum. 52:315-20, 1998.
Abstract
Long-term administration of the monoamine
oxidase inhibitor (-)-deprenyl (0.5 mg/Kg) for up to 20
months significantly increased mortality in the male Wistar rat, whereas the
dopamine agonist pergolide (0.4 mg/Kg) and the antioxidant
diethyldithiocarbamate (400 mg/Kg) had no significant effect on mortality.
The increased mortality was not related to dietary intake or body weight of
the rats. This is of interest in the light of recent evidence that
(-)-deprenyl increases mortality in humans.