Re: AGING: Accumulation of DNA damage

From: Scott Badger (w_scott_badger@yahoo.com)
Date: Mon Jun 26 2000 - 17:21:47 MDT


--- "Robert J. Bradbury" <bradbury@aeiveos.com> wrote:
> It [cloning problems] does however in my mind
provide a significant
> amount of gravity
> for the DNA Damage theory as being a factor in the
> aging process.
> The developmental genes in an adult can accumulate
> mutations and
> you will never know it. But if you try to grow a
> new adult using
> those genes with accumulated mutations, then the
> results detailed
> above are a likely result. It also suggests that if
> DNA mutations
> are gradually causing deaths in the latent stem cell
> population
> in the body, that over time you will have less and
> less reserve
> capacity from which to renew yourself. Only if you
> can reactivate
> the program that *expands* the remaining subset of
> "perfect" stem cells
> (as probably happens during development) will you be
> able to
> revserse this aspect of the aging process.

You've probably taken this into consideration, but
would Dr. West's research tend to refute this
hypothesis?

"Now, in a major new paper published in the April 28,
2000 issue of the journal Science (1), a group led by
Dr. Michael West has reported what may be the most
revolutionary advance in cloning research so far. They
have found that cloning can totally reverse cellular
aging."

http://www.lef.org/featured-articles/apr2000_clon_01.html

Scott

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