deprenyl fails to alter aging in flies

From: Doug Skrecky (
Date: Sat Jun 17 2000 - 06:26:10 MDT

  Prolongation of life in an experimental model of aging in Drosophila
  Neurochemical Research. 24(2):227-33, 1999 Feb.
  (R)-Deprenyl, the archetypical monoamine oxidase-B inhibitor, has been shown
  to increase life-span in a number of species. Although many theories for this
  effect have been suggested, for example, an increase in superoxide dismutase
  (SOD) activity, the mechanism of action has yet to be
  elucidated. To investigate this phenomenon, we have examined the effects of
  (R)-deprenyl, and some aliphatic propargylamines, in an experimental aging
  model in Drosophila melanogaster. Both wild-type Oregon-R type flies, as well
  as a SOD knock-out mutant
  strain were used. Flies obtained from a series of paired mates were divided
  equally among treatment groups. In all studies, flies were treated for the
  duration of life following adult emergence. The aging model consists of
  substitution of sucrose with galactose in the regular food media of the
  flies. Initial experiments confirmed that such a substitution resulted in a
  significant (p < 0.01, Breslow test) reduction in mean and maximal life-span
  of flies, an effect not due to nutrient deprivation. Inclusion of
  (R)-deprenyl and the aliphatic propargylamines in the media, at average daily
  doses in the range 0.5-1 ng/fly/day, led to a significant increase in mean
  and maximal life-span of galactose-treated, but not control flies. This
  effect was seen in both wild-type and mutant flies.

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