A very straightfoward explanation for mitotic "misregulation" is that cells
are selected for it. The "misregulations" consist of continuing with
division when the cell would normally stop. Such cells thus divide more than
"normal" cells and become more common within your body just by standard
ecological selection. It's "misregulation" for you, but not for the altered
cells (more specifically the altered genes), which are gaining by it. It's a
classic case of individual (= cell) benefit and group (=you) loss.
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