Authors
Diani AR. Shull KL. Zaya MJ. Brunden MN.
Institution
Upjohn Company, Kalamazoo, Mich 49001, USA.
Title
The penetration enhancer
SEPA augments stimulation of scalp hair growth by topical minoxidil in
the balding stumptail macaque.
Source
Skin Pharmacology. 8(5):221-8, 1995.
Abstract
The purpose of this study was to determine if
the penetration enhancer
SEPA (2-n-nonyl-1,3-dioxolane) would augment the scalp hair
growth effects of topical minoxidil in the balding stumptail
macaque. A 1-in2 area on the balding scalp of 40 adult
female monkeys (four drug-treated and four vehicle-treated groups of 5
monkeys each) was topically treated 5 days/week, q.d. or b.i.d., with
approximately 250 microliters of minoxidil-SEPA (2.5% minoxidil,
weight/volume in 10% SEPA, 25% propylene glycol and 65% isopropyl alcohol),
Rogaine topical solution (TS, 2% minoxidil, weight/volume in 20% propylene
glycol, 60% ethanol and 20% water) or respective vehicles (without drug) for
16 weeks via paintbrush application. Scalp hair was collected by shaving and
vacuuming the dosed area at baseline and at 4-week
intervals. The shaved hair was filtered, weighed and
recorded as the change from baseline. The
q.d. and b.i.d. minoxidil-SEPA groups displayed a significant increase in
hair weight compared to their respective vehicles at week 4
whereas q.d. and b.i.d. Rogaine TS groups were not active until week 8 and
12, respectively. Both minoxidil-SEPA treatments produced significantly
greater cumulative hair weight over the entire 16-week study
compared to either of the Rogaine TS
treatments. Comparable increases in cumulative hair weight were evident
between q.d. and b.i.d. minoxidil-SEPA groups and between q.d. and b.i.d.
Rogaine TS groups.(ABSTRACT TRUNCATED AT 250 WORDS)