Space-filling isn't very usefull in the early stages of the pathway
I'm describing. The main goal is to produce hinges from proteins attached
at a few points to the adjacent protein or held in the right place by
dna attached to both proteins, and build "arms" with several degrees
of freedom out of this.
Attaching small pieces of dna to proteins is a bit easier than attaching
proteins to proteins, and Bruce and Markus say they have new ideas for
doing it better (they're keeping those ideas private for now).
There will be steps at which precise positioning of 2 proteins will
be important. The dna scaffolding should be able to provide this in the
earliest stages. In later stages, the "arms" will push the proteins into
appropriate places.
-- ------------------------------------------------------------------------ Peter McCluskey | pcm@rahul.net | Has anyone used http://crit.org http://www.rahul.net/pcm | to comment on your web pages?