Most drugs (at least those forbidden by law) DO have an intense effect,
no matter what you think about them. I think set and setting is less a
question of whether it does work or not, but whether it will be useful
or useless for you (maybe that's what you actually meant).
I'm quite sure that the less a drug is dependent upon set and setting,
the higher the risk of abuse in terms of "making the drug do something
that you should do yourself". According to a study about drug-abuse,
hallucinongenics (which are totally dependent on set and setting) have a
rather low "abuse-potential", while opiates are frequently "abused" (if
anyone's interested I can dig it out - unfortunately, I have the mail on
another computer...)
later,
Holger
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