Re: Mice without Telomerase

CurtAdams (
Sat, 17 Jan 1998 14:17:07 EST

In a message dated 1/16/98 11:21:04 PM, wrote:

(Re telomerase-less mice)

>I must admit that I would also expect the mice to have severe reproductive
>difficulties, but if they really have gone through 4 generations then the
>trouble can't be too bad. This probably means that we really don't understand
>what's going on very well. Lots about this puzzle seem contradictory, but the
>parts must fit together somehow.

One possible explaination is that mice achieve senescence via a different
mechanism. They would then have no compelling need to use telomerase to
keep differentiated cells on a tight leash; they could have a backup system
or just long enough telomeres to tolerate lots of divisions.