localized drug delivery to brain

Mon, 10 Feb 1997 20:46:05 -0500 (EST)

A few months ago I got a one on one presentation from a neuroscientist
(Dr. M. Kubek, Indiana U. Med. Center, Indianaoplis)
working down the hall from my work-study job.
Here's a brief version of then peek he gave
me of
his successes with inhibiting seizures in rats. It just dawned on me
today that his technique could be modified to give a constant,
consistant, and localized dose of, say, dopamine or {insert favorite
nootropic chemical}.

The brains of a group of rats were conditioned to have siezures at the
prompting of a specific stimulus. After conditioning, a portion of those
rats had a "micro disc" (I believe that's what he called it) implanted in
their brains at a site known to be envolved in a particular kind of
siezure. This micro disc is a small soluble, ...um... thing, that
releases a chemical that naturally occurs in human
brains as well as rats. This chemical is known to inhibit siezures in
both rats and humans. When exposed to the stimulus, the rats without the
micro disc showed no change in their response to the stimulus, while
those with the implant showed a clear decline in brain activity
associated with siezures.
I'm sorry about the missing details and any slight
misrepresentaions of exactly what the experiment entailed, but the result
of the experiment is clear; The microdisc Dr. Kubek used in this
experiment delivers a constant, consistant supply of chemical to a
localized region of the brain. He went on to explain that humans with
severe forms of epilepsy could have a permanent window in the skull
through which a new micro disc could be installed on an out patient basis
every few months or so when the previous disc had disolved. This is an
alternative treatment to i.v. injenctions, or in some cases, a
frontal lobotomy.
Such a drug delivery system could be used for extropic purposes
(and, of cours, involuntary mind control), however drilling a hole in a
perfectly good skull is not something I'd just jump into. If the above
method is not suitable, maybe it can be a starting point for one that is.
This work is not yet published, though it was presented to a
neuroscience conference in Washington D.C. around Nov. '96. I'd be
willing to find out when and where it will be published for an interested

Please pardon any awkward sentences. Pine does not allow me much
latitude for editing.


Michael Bowling