From: Robert J. Bradbury (bradbury@aeiveos.com)
Date: Thu Jan 10 2002 - 08:41:44 MST
On Thu, 10 Jan 2002, Harvey Newstrom wrote:
> With this additional information, I am now concerned that CoQ10 may be
> detrimental in higher amounts. I will have to tune my life-extension
> program now.
Review sources, presumably lots on the net now, carefully.
Most dietary sources of Q10 are in non-plant food sources.
"Muscle" contains a lot of Q10. If you don't eat much of it
then you should supplement. Additionally if one is on cholesterol
inhibiting medication and its one of the drugs designed to inhibit
the HMG-CoA-reductase enzyme (many "statins"), that is going to
decrease your endogenous Q10 production (both cholesteral and
Q10 synthesis are downstream from that enzyme).
It is probably going to be difficult to get the dose right
calculating from first principles (diet, weight, etc.).
Better in the long run is to have tests done and try to
maintain your Q10 level at the mid-high end of "normal".
Note -- the side effect of Q10 quenching superoxide (this needs
to be researched more(!)) would be to diminish uncoupling meaning
potentially your temperature should run low and/or your weight could
increase. But all this fits in nicely with the CR model --
low glucose levels means a low flux through the mitochondrial
electron transport chain means it never gets "backed up" generating
superoxide in the first place.
I'd say place your emphasis on keeping your glucose levels as low
as you feel comfortable without feeling lethargic.
> Have you considered moderating an ExI NodeNet forum on life extension....?
Can't. Keeping up with this stuff would be a full time job.
I'm getting one of those trying to put us in the position of
engineering better solutions to these problems. Trying to extend
lifespan with diet is like trying to thread a needle while wearing
oven mitts.
Robert
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