Re: Progress on the protein folding problem

From: ct (
Date: Tue Feb 13 2001 - 07:51:21 MST

From: "Jeff Davis"
>Rosetta may hold key to predicting protein folding
>...predicting the three-dimensional structure of a
> folded protein from its linear sequence of amino acids.

>The article does not say what computational resources were applied to the

Is this Rosetta, as in Rosetta Inpharmatics, Inc(RSTA) of Seattle? This
would be one of the companies that Leroy Hood helped to start after leaving
the U-dub. Remember Hood? Gates brought him up from CA to head a new
Molecular Biotechnology Dept at the UW. His departure from the U to enter
the private sector rustled some feathers I believe.
A statement that I found noteworthy in the article was:

["Interestingly, some of our predicted structures were quite similar to
structures of proteins that had already been solved, and which turned out to
have similar functions to the target protein, even though there was no
significant sequence similarity. Thus, our predicted structures provided
clues about function that could not be obtained by traditional sequence
comparison methods," Baker said.]

This archive was generated by hypermail 2b30 : Mon May 28 2001 - 09:56:39 MDT