> For those who may not know, 5-HT is serotonin. About
> the degree to which PCP raises serotonin, or 5-HT,
> the journal Neuroreport (1998;9(13):2985-8) states:
> "We here report for the first time that
> systemically administered PCP (5 mg/kg, s.c.)
> increases extracellular 5-HT levels in the rat
> medial prefrontal cortex (to 322%) and dorsal
> hippocampus (to 233%)."
This is very interesting indeed, specially because other
serotonergic drugs don't modify your behavior so drastically
LSD can give you a bad trip, but people rarely becomes as
aggressive as to kill somebody (although it might happen
if the person is too scared)
I suppose this is because LSD and other serotonergic drugs
work in a different way, the exact mechanism of LSD is not
completely known yet, and what MDMA does is to make you
release all the serotonin stored in your neurons.
I wonder if a person whose behavior is affected by ssri's
could be calmed down administering a dose of MDMA to
deplete their serotonin levels, however some ravers use
prozac after 6 hours of MDMA ingestion to prevent sero-
tonin depletion by blocking the uptake receptors that
recapture serotonin and oxidize it with monoamineoxidase
so I wonder what kind of effects this combo could possibly
somebody with more knowledge about neuroscience than I
would like to suggest some theories?
> >PCP interacts with acetylcholene and the opiate system and is a nmda
> >antagonist....it dose not block the reuptake of serotonin....
Yes, that's why the effects of prozac and PCP are so different
acetylcholene is a neurotransmitter used to control your muscular
movement among other things, usually drugs that inhibit it's
production
can produce full blown hallucinations comparable to psychoses
(a lot more than those produced by LSD) but they can be used
as sleep or motion sickness aids too
> IAN: Yes, PCP is an NMDA antagonist, however, as
> we see in the cited study, behavior modification
> is linked to PCP's action on 5-HT. Several months
> ago I contacted Lance Kreplick, M.D., <LKJK@aol.com>
> who had written a report posted to the web about PCP.
> I asked if PCP is an SSRI. He said: "Yes it is an SSRI."
I suppose then than the dissociative effects PCP has are caused
by it's interaction with acetylcholene, and the behavior modifications
because of it's action on 5-ht, if it's effects are similar to those
of prozac, then not everybody who uses it becomes a violent person.
What I still don't understand however, is why PCP causes dissociative
effects instead of the hallucinations of traditional acetylcholene
drugs
like scopolamine, my hunch is PCP has a mechanism more complex than
this
somebody knows it?
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