Re: Longevity Breeding

Date: Mon Feb 07 2000 - 10:47:25 MST

In a message dated 2/7/00 5:54:16 AM Pacific Standard Time, writes:

> However, I've been worried
> for quite some time that "disassembling" the process does not
> equate with "fixing" the process. Thus, some of you have seen
> me argue at Extro4 and on the list for things like sequencing
> elephant and newt genomes, molecular modeling of cells, etc.

Elephant I get, but why newts? Birds and bats would
be great targets for sequencing since they blow the
metabolism/longevity tradeoff so drastically.

>Namely, to replicate Michael Rose's work in breeding long lived
>individuals. Michael and others have done this with Drosophila
>and now Michael has a low level effort attempting to do this in mice.

Dunno if Michael is working on such a project, but it's already been
done: Nagai, Lin, and Sabour 1995. "Lines of Mice Selected for
Reproductive Longevity", Growth, Development and Aging 59:79-91.
(Michael knows of this and cites it) Seems like a great system to
investigate mechanisms but I'm not aware of any such work. I
hope they've still got the selected lines.

>The question becomes are there other species that one might be able
>to use for similar experiments?

Oooh, oooh - how about temporary habitat shrimp? Nature's already
done the longevity selection for you. (guess what I'm working on
this quarter :-) Those slow-aging island possums could also be a
pre-made model.

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